LARPs in treatment of Fibrosis
LARPs or La- related proteins, are a superfamily of proteins present on both plants and animals. What is LARP6? LARP6 is a crucial RNA-binding protein. The key function of this particular protein is it regulates type I collagen synthesis by binding to the 5’ stem-loop structure on collagen mRNAs. Histology findings of skin biopsy showing extensive fibrosis with dense subepithelial collagen deposition, sparse inflammatory cell infiltration (black arrow), and entrapment of the dermal adnexa between the collagen fibers (white arrow) (a, b). Atrophy of the epidermis and loss of epidermal papilla (c) (H&E stain ×10). Ref. Nakalema G, Egesa WI, Kumbakulu PK, et al. Sclerema neonatorum in a term infant: a case report and literature review. Case Rep Pediatr. 2020;2020:8837064. https://doi.org/10.1155/2020/8837064. Researchers at Florida State University’s Institute of Molecular Biophysics and Department of Chemistry and Biochemistry have uncovered how a protein in the human body ...