Posts

LARPs in treatment of Fibrosis

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LARPs or La- related proteins, are a superfamily of proteins present on both plants and animals. What is LARP6? LARP6 is a crucial RNA-binding protein. The key function of this particular protein is it regulates type I collagen synthesis by binding to the 5’ stem-loop structure on collagen mRNAs. Histology findings of skin biopsy showing extensive fibrosis with dense subepithelial collagen deposition, sparse inflammatory cell infiltration (black arrow), and entrapment of the dermal adnexa between the collagen fibers (white arrow) (a, b). Atrophy of the epidermis and loss of epidermal papilla (c) (H&E stain ×10). Ref. Nakalema G, Egesa WI, Kumbakulu PK, et al. Sclerema neonatorum in a term infant: a case report and literature review. Case Rep Pediatr. 2020;2020:8837064. https://doi.org/10.1155/2020/8837064. Researchers at Florida State University’s Institute of Molecular Biophysics and Department of Chemistry and Biochemistry have uncovered how a protein in the human  body ...

How vitamin D might slow aging

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Vitamin D, the familiar   “sunshine vitamin,”   is stepping into the spotlight for a very different reason: it may help slow cellular aging from the inside out. A new analysis of a large clinical trial suggests that daily vitamin D supplements can protect tiny structures on our DNA called telomeres, which are closely tied to how fast our cells, and ultimately our bodies, grow old. Vitamin D or cholecalciferol, known as "sunshine vitamin" might help slow down cellular aging Photo by Vitolda Klein on Unsplash How vitamin D might slow aging Telomeres sit at the ends of chromosomes like the plastic tips on shoelaces, shielding our genetic material each time a cell divides. As the years pass, these caps naturally shorten; when they become too short, cells stop dividing properly and are more likely to malfunction or die, raising the risk of diseases such as cancer, heart disease, and osteoarthritis. In the VITAL trial, researchers followed 1,031 older adults for four years and fou...

What really is PCOD and PCOS? All you need to know

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Nutritional Modulation of Polycystic Ovary Syndrome (PCOS): A Metabolic and Hormonal Perspective A representation of the symptomatic exhibition Credits: Dr. Manisha Jain Abstract Polycystic Ovary Syndrome (PCOS) is a complex endocrine–metabolic disorder characterized by hormonal imbalance, insulin resistance, and chronic low-grade inflammation. Emerging evidence highlights nutrition as a primary, non-pharmacological intervention capable of restoring metabolic homeostasis. This blog presents a structured, scientific overview of how dietary composition influences PCOS pathophysiology, emphasizing glycemic control, macronutrient optimization, anti-inflammatory strategies, and sustainable lifestyle integration. 1. Understanding PCOS as a Metabolic-Endocrine Disorder 1.1 Definition and Prevalence PCOS affects women of reproductive age and manifests through: Oligo- or anovulation Hyperandrogenism Polycystic ovarian morphology Beyond reproductive...

Insomnia Keeps Brain in Daytime Mode

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Why Your Brain Won't Switch Off at Night: The Insomnia Clock Glitch Revealed Tired of a racing mind stealing your sleep? A groundbreaking University of South Australia study uncovers why chronic insomnia keeps your brain locked in high-alert "daytime mode" deep into the night—it's not just stress, it's a circadian rhythm breakdown.​ Insomnia traps the brain in daytime mode—alert, restless, and unable to power down—turning night into an extension of wakefulness rather than a gateway to recovery. Photo by Megan te Boekhorst on Unsplash The Lab Discovery That Changes Everything In a 24-hour "constant routine" experiment, 16 insomniacs and 16 good sleepers stayed awake in dim-lit bedrest, logging thoughts hourly on tone, quality, and control. Healthy brains peaked in afternoon problem-solving, then plunged to nighttime disengagement. Insomniacs? Peaks delayed by 6.5 hours, with blunted drops—staying goal-directed and emotionally engaged when they should pow...

How to write a blog

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What do you really need to write a blog? Once you start, you don't stop, you improve day by day Credits: Fresh Science Trends Acclimatization Phase: First things first; what really is a blog?  A blog is a regularly updated online publication—either a single web page or a full website—where one or more authors share content such as articles, news, opinions, tutorials, or personal stories, usually arranged with the newest posts first and often allowing reader comments or interaction. The term comes from “weblog,” originally meaning a personal or topical log on the web, and today covers everything from casual diaries and niche hobby sites to professional news outlets and business content hubs. Choose which blogsite you will choose to make your blog.  For an easier blogging approach, start with simple, hosted platforms that handle all the tech for you: WordPress.com and Blogger are beginner‑friendly, free (with upgrades), and good for article‑style blogs.​ Medium and Substack le...

Tricking the brain to make exercise feel easier

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Hack Your Brain to Make Workouts Feel Effortless: The Tendon Vibration Trick Dread the burn of a jog or bike ride? New research shows you can "trick" your brain into perceiving exercise as easier—pushing harder without feeling it. Breath, balance, and sunrise light: where strength feels soft and movement turns into quiet meditation Photo by kike vega on Unsplash The Simple Experiment Université de Montréal's Prof. Benjamin Pageaux strapped vibrating devices to volunteers' Achilles and knee tendons for 10 minutes before a 3-minute cycling test. Result? Same perceived effort, but higher power output and heart rates—muscles worked harder while brains registered "moderate." ​ How Vibration Rewires Effort Vibration tweaks spinal neurons and neuromuscular spindles, scrambling signals to the brain about movement strain. "It alters perception, making tough feel tolerable," Pageaux explains. Published in  Journal of Sport and Health Science , this boosts m...

Warmth and Hugging Strengthen the Feeling of Being You

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Warm hugs do more than feel nice—they quietly tune the nervous system, deepen body awareness, and strengthen the sense of “this is me.” When a warm hug melts the world away and, for a moment, you remember exactly who you are and who you belong to. Photo by  Anastasia Vityukova  on  Unsplash Why warmth changes how you feel about yourself A new review from Queen Mary University of London and the University of Pavia highlights “thermoception,” the brain’s reading of skin temperature, as a direct skin‑to‑brain channel for shaping bodily self‑awareness. When the skin feels warmth—from a hug, a blanket, or a heated room—the brain updates its internal map of the body, reinforcing the feeling that the body belongs to us and grounding our sense of self. These temperature signals don’t just keep us alive and comfortable; they influence emotion, identity, and how present we feel in our own skin. When temperature signals go wrong The authors show that disturbed thermal perception oft...