Science Trends

Laurence Zitvogel,   Nicola Segata,   Jonathan Peled  and  Maria Rescigno   Abstract Simple Summary The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies Cancer immunotherapy is a treatment modality that involves the stimulation of the patient’s immune system to fight off tumors. Although efficient in limiting the disease progression of several solid tumors, including lung cancer and melanoma, some patients may have poor outcomes. This review focuses on the role of the gut microbiota (the microbial community residing in the gastrointestinal tract) in immunity and cancer immunotherapy. Manipulation of the gut microbiota with dietary interventions or fecal microbiota transplantation to enhance response to immunotherapy could pave the way for personalized therapies with improved efficacy. Chaired by  Luca Danelli The microbiota can influence the immune system and modulate response to cancer immunotherapy. In this webinar, our spe...

  Picture: A Heart, Source:  Magic Design™: Free Online AI Design Tool New Insights into the Heart's Circadian Mechanism Scientists have uncovered a new cellular mechanism that allows the mammalian heart to align with circadian rhythms, shedding light on why some individuals may face increased cardiac risks. Circadian rhythms, biological processes that operate on a 24-hour cycle, govern crucial bodily functions such as sleep-wake cycles, metabolism, and cognition. The heart, long known to follow this biological clock, experiences changes like elevated heart rates in the morning and reduced rates at night. However, the precise cellular processes driving these fluctuations have remained elusive. Discovery of an Ion Transport System Researchers at the MRC Laboratory for Molecular Biology at the University of Cambridge, led by circadian biologist Alessandra Stangherlin, have identified an ion transport system in mouse heart cells that plays a pivotal role. This system enables h...

  Credit: Unsplash/CC0 Public Domain Summary of Honey's Microbiology and Implications on Human Health 1. Honey Composition and Microbial Relationship Honey is composed mainly of sugars (fructose, glucose), water, and organic compounds. Microbial diversity in honey stems from bee digestive tracts, environmental sources (soil, plants, air), and hive conditions. Factors affecting microbial composition include: Honeybee microbiome Floral nectar sources Geographical hive location Environmental conditions Microbial examples in honey: Beneficial microbes: Lactic acid bacteria (e.g., Lactobacillus , Bifidobacterium ) contribute to acidity, probiotics, and antimicrobial properties. Undesirable microbes: Yeasts (e.g., Saccharomyces , Candida ) in high-moisture honey can lead to spoilage. 2. Honeybee Microbiome's Role Honeybee gut microbiomes (e.g., Enterobacter , Serratia ) are crucial for honey's chemical properties and bee health. Disturbance in this microbio...

Date: December 20, 2024 Source: Royal Astronomical Society Summary: One of the biggest mysteries in science -- dark energy -- doesn't actually exist, according to researchers looking to solve the riddle of how the Universe is expanding. For the past 100 years, physicists have generally assumed that the cosmos is growing equally in all directions. They employed the concept of dark energy as a placeholder to explain unknown physics they couldn't understand, but the contentious theory has always had its problems. Now a team of physicists and astronomers are challenging the status quo, using improved analysis of supernovae light curves to show that the Universe is expanding in a more varied, 'lumpier' way. One of the biggest mysteries in science -- dark energy -- doesn't actually exist, according to researchers looking to solve the riddle of how the Universe is expanding. For the past 100 years, physicists have generally assumed that the cosmos is growing equally in all...

 I'd like to plot the blog down in postulates so that it would be considerably easier to study and understand. Heart Failure: Causes, Types, Diagnosis, and Management Heart failure is a condition in which the heart cannot effectively circulate blood to the body's organs. Depending on the underlying cause, heart function may sometimes return to normal with appropriate treatment. Heart Attack In Women Silent Killer Types of Heart Failure Systolic Heart Failure (Reduced Pumping Function): The most common type, characterized by a reduced ability of the heart to pump blood. Symptoms include: Shortness of breath. Fluid retention, causing swelling in the legs or abdomen. Fatigue or subtle signs in some individuals. Diastolic Heart Failure (Impaired Relaxation): In this type, the heart's pumping ability remains normal, but relaxation is impaired, leading to circulation issues. Diagnosing Heart Failure Heart failure is diagnosed by assessing the heart's pumpi...

An international research team found evidence that heart muscle can regenerate after heart failure in some people with artificial hearts Date:  December 20, 2024 Source:  University of Arizona Health Sciences Summary: P hysician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure. A research team co-led by a physician-scientist at the University of Arizona College of Medicine -- Tucson's Sarver Heart Center found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure. The results were published in the journal Circulation. According to the Centers for Disease Control and Prevention, heart failure affects nearly 7 million U.S. adults and is responsible for 14% of deaths per year. There is no cure for heart failure, though medications can slow its progression. T...