Abstract Artificial sweeteners like saccharin, commonly used as sugar substitutes, are revealing surprising capabilities in combating antibiotic-resistant bacteria. Recent research indicates that saccharin and similar compounds, such as acesulfame-K and sucralose, can inhibit the growth of multidrug-resistant pathogens like Acinetobacter baumannii and Pseudomonas aeruginosa . These sweeteners disrupt bacterial biofilm formation and motility, and they can enhance the effectiveness of existing antibiotics by increasing bacterial membrane permeability, leading to cell lysis. Notably, acesulfame-K demonstrated potent antimicrobial activity in ex vivo wound models, suggesting potential therapeutic applications. However, there's a complex side to this narrative. Studies have shown that artificial sweeteners can also promote the spread of antibiotic resistance genes. They do this by increasing bacterial cell membrane permeability and stimulating the expression of genes involved in D...
Comments
Post a Comment
Please comment on this blog-