Deep Space Travel May Damage Astronauts' Gut Functions: Study

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    HIGHLIGHTS

  • Exposure to cosmic radiation might damage gastrointestinal functions
  • Study raises concern about risk of tumour development in stomach, colon
  • A mouse's small intestine was used as a model system for the study

Exposure to galactic cosmic radiation during deep space travel, such as to Mars, might significantly damage gastrointestinal functions in astronauts, say researchers, led by one of an Indian-origin.
The animal-based study also raises concern about high risk of tumour development in stomach and colon.
"Heavy ions such as iron and silicon are damaging because of their greater mass compared to no-mass photons such as x-rays and gamma (y)-rays prevalent on earth as well as low mass protons in outer space," said Kamal Datta, Associate Professor at the Georgetown University in the US.
"While short trips, like the times astronauts travelled to the Moon, may not expose them to this level of damage, the real concern is lasting injury from a long trip such as a Mars or other deep space missions which would be much longer," Datta added.
The gastrointestinal tract is a self-renewing tissue with continuous cell division/proliferation.
The mucosal (top) layer of cells is replaced every three to five days through coordinated migration of new cells from the bottom of a flask shaped structure called crypt towards the lumen of the gut.
"Any disturbance of this replacement mechanism leads to malfunctioning of physiologic processes such as nutrient absorption and starts pathologic processes such as cancer," said co-author Albert Fornace Jr., Director at the varsity's NASA Specialised Center of Research (NSCOR).
For the study, published in the journal PNAS, the team used mouse's small intestine as a model system and exposed mice to a low dose of iron radiation.
"It is important to understand these effects in advance so we can do everything we can to protect our future space travellers," Datta said.

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